Endoplasmic reticulum

The endoplasmic reticulum is situated around the nucleus as it is the main site for protein synthesis in the cell

Welcome to the How a Protein Folds in, and is exported from, the Endoplasmic Reticulum WikiEdit

This wiki is designed to act as a useful learning resource and revision tool for undergraduates studying the endoplasmic reticulum in the cell biology module, topic areas covered in this wiki are: The function of the endoplasmic reticulum, translation of proteins into the endoplasmic reticulum, protein folding and glycosylation in the endoplasmic reticulum, protein misfolding and exportation of proteins from the ER.

After reading through all the information and looking at the explanatory slideshows you might want to test yourself with our quiz to check your progress. Just click on the links below to manoeuvre the wiki and to return to this home page just click the orange title, 'Protein folding in the Endoplasmic Reticulum Wiki', in the top left corner of the screen.

Function of the ER: A brief explanation of the structure and function of the endoplasmic reticulum.

Translation into the ER: How proteins enter the endoplasmic reticulum with the help of ribosomes and translocons.

Folding and Glycosylation in the ER: How proteins are folded within the endoplasmic reticulum and carbohydrates added to make them ready to function.

Protein Misfolding: Why do proteins sometimes misfold and how does the cell prevent them causing damage?

Exportation from the ER: How completed proteins are exported from the endoplasmic reticulum and transported to where they are needed.

Summary Quiz: Finally, a quiz to test your understanding of all the topics covered.